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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a6319415e0d0fafde8e011622dc33b68eff8df6083a93ba749e654d48adda415' 
  AND token = 'yMz33CX+qbtSyHY1vhy5wreJAnUMak0g0dmXxj3JmFo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}