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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0ff2f1300c8334737b8410912769a7a218f7480c143939742c6a98bbedd7ef58' 
  AND token = 'zs+j0IFWye/tPd4x1mij1fgsB5wWjJVu44opNumdFsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}