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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '741d3e67cd664e1e1995926d70b5ba79e5bcf9587327e2b47bd5d66b44cb6f1e' 
  AND token = 'ezOUQYC45vANWsT/ZLCU7eT76DgrEkqkHgQZRMdCMys=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}