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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25d8d1f6f566d6105cece1a0b63d3364e7816232e7b5dc67d3dd36c216460a54' 
  AND token = 'FnrbvkZrdSEvxKJ69XDDnzcLOHR6Z28BAMCrmtb9EHI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}