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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43cb5f7f13cc6780691fa6cc8b89d66711160310a8944b3055e42709d0dc8405' 
  AND token = '2kidqH+RFpul9EDXdJqi4ewfTJzOeP20mtGhOwG1t4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}