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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43db2e73952208ef947115e54e28cac82ba336c8dfc7bc2684feda817874c9c1' 
  AND token = 'UDfmx444JhEjYW6fn25OVJm2mdmyMdRqO33aV/Z4zRw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}