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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b15c9bb54371fdef57f2606a54a8bb1a38701f6490633d8b72a4de31b3fdbd31' 
  AND token = 'ZEn8+sbR8GdyUML89HcXeuqN0FT7ZJgdzy8f0WawWUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}