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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '007005464df8506858d0128cd91ba025d138f0b83e3ef31e8bce158f3fba2423' 
  AND token = 'IO5fecJZOEcUtlHBjhPw6Up4ULOvbXIFcfSvERWSrmU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}