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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b6fd5f4bda7032cd0246901188a303b4a0394fc7fa0000185781508109a4048f' 
  AND token = 'Oe+ua9q1uUkmuonIQZxFHZJyB+d+QbkyF2KlfHQqUr0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}