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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5411ddf0c1c78c1a34b04024fcf00f26506fc18fd7438c9cd2af1239bba10f06' 
  AND token = 'F7zfh7tLOC/5/WGz7yt0Cd4L3stG5mz0U9T8t0f0uPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}