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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '73ded5055aeef268cd435391b2e255a6bc3e3e0b00c56985c70069807e20f5c9' 
  AND token = '/0Ocanfuh+aaRzRLgPUwK8oGp+MrYsUcB3tlx0xDFUY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}