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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c3d8d68c3c8da3b3a81bca9403fc9c664d7c1b71413a973554c85f724c27894' 
  AND token = 'mc+Rl6SsfJZ5StoSTD5dFBxkXH9Nnt5DiS20rfeiRh4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}