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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f13eb7c5d067a3e9fb3f32c7a4c61a0e9ab361163d134330b520fe355c54f78' 
  AND token = 'a1lyGk0v43Bc9/f785myzC/JLH5OG5Gg+jqyKYEuoOc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}