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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7597e2df5bff6c8759ee2b3d9db243ddf5978e945e9a15080f7da49e04d65601' 
  AND token = 'jk9nb0cMkOPODMX6WETK9zxNb3W04JjfGDRh1OMzJ2U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}