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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a9dfa943068969fb70e255764cf7560a4f771d7a45470b030b71a27bde689920' 
  AND token = 'ePO8q+9ZdWfwwoKD1O8s617TDhFvUNP4Wk3KN6gnFfs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}