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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '300eb5bb607f431f0d7a4fd3250bbc315b06d51b6360587577e36c3658d6f259' 
  AND token = 'GCRqGPj1pNdhvGcps0WxIatYXO21bOv1zkrNWGVsf9I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}