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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf6e61115066044f4abe26103179104c08afb4285076b5b55b00df481420daa3' 
  AND token = 'a8EAiMPfcbF3+Uz68KsAQQ1whEoT0jUPfkTpxkzhg4Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}