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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '425c8c72e32223d2501d60539cee448e239f1aeee850cc9dc1d6dcc1d4bb9d78' 
  AND token = 'Y1hwKPjdcdkrMBtEL0WpAfmmKfZ3yZlO0XEqo0YDETk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}