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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a161a3053c8f8617b4b7288114de9c7b002215dbb172ba270d9a6ae06c35730' 
  AND token = 'tG48laIeSOiZTRIMTaD68Qb8AJAMK8wsVq7ZEKJNEOs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}