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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43daf2e0387a91435e26115327abd0ae34c3afcddcdd06bb9f19497c9d633e27' 
  AND token = 'iw4qoJCnTWcgfgxfV1v8sV8sa85Sr6pG0qYXPzgXUy0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}