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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd7781c447aaf8e4b78579a9cf3f6cceb5742e7a55162f8dcae5d69529008c65' 
  AND token = 'JSZ3IUIJ6q1U6uO/Xw32LrNnZw/poq18FwZvV3RwtVo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}