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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '800d6550060c8a7acc895fc40ec79cbc244c6e1dd43c0aca813c773b6c9d40c0' 
  AND token = 'EMQstT3kH7XC0zVvzK2APy4P3UGNiH1ZQyIU9rJN88Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}