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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46fc707c0023f2c97b12c5f2215aabbf8d5404fc3c76a94160b5728e2e38eead' 
  AND token = 'qtUUHOsCIUdjYrm2zxQUx197e1ChJWt+IqfatXTIubA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}