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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '409b2e7547f870a49204715bb59574dac44051e7ea1e5e20bcd99e5f29e12016' 
  AND token = 'DS7e8gJLX1aOFWe/eJwuQhWW1UXIGIb8B0TADsicKmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}