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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f03f170f789269adbc02d4d263678a3b6c139a7b2ea8e8cc025ebc019c39d535' 
  AND token = 'HdWTP3sIHlTXDP+m/0g2nAq+QzcfHq0YpA9xltY2ScY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}