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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd899d1509fc2059c7f2f0cfc7c660721adf4c8c83655acdfa1c244e62ebda7a7' 
  AND token = '+lFB5wVnZEQh9ePSC+LoeLPRcNGRM9rEXMiQpV9EGMs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}