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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e1246160324ccc4cacd86c70b074384153dd4d0fb03f3a305d49495eefdd21d' 
  AND token = 'MGI4Hg3S/v66v3Vng2jPaSilxdFI3PscvrKBs9dVKWI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}