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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46e876351a0d9bc3332b22212901a2c49dd7063e32ab081a46ede9224a5a7397' 
  AND token = 'pOG9xuBYubIcklhLL0umBUnsv1pL7Y0lmELDQNB+5UI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}