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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b3f1abe0dfaa3a9beffafd9b35a8541d9f9dc11361c082a3eedb0be0b4cbf492' 
  AND token = 'uX8BE/YtGaSyZKbZgFEoQI0wCnBNbBQXvxZIqSL5a38=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}