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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c107b7feecd43de47a9aa17f6a5cceacc40cb1225760e8ff5b16a72c20b6935' 
  AND token = 'ZGpTA4NzCMfTrzt7SKUj+sbgExR49cwU7JgjLKh0bPE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}