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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8750a9520068c41f873acb036f069bbb5211c7e2d8cb4a801a591b2a0ffeb72' 
  AND token = 'xQ6L7kZFc3NXvYAXcCBajRO1Q5co7QMKTV7QMnsMq3s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}