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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c81d738a2c832db62c8d9757ee64b07997aef0ba7db6e2da27ed1ab033713726' 
  AND token = 'eScOUoC8lUGoVyM9F8efDTMtM9aQEZBvSUQGqTTP7aY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}