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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45343b02a50a4ccf4a1777b9ab82a378554e2fc6bfd30a2e226da48f2da06236' 
  AND token = 'YOz8WBvaiRCrJsqPAK2S+fys8N65vijsYnrLpzCV8TQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}