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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aa3af6ebee61949011ce7ef535030d85d8daa3377f9d71c72d208c23536b600a' 
  AND token = 'wF1XlfPg6lXzp8v/n+DfIi4b3+/8qacNNiz0HkMwj7c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}