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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '350e1f23df7cd9dcf93cf4c01203da858bd7598d4c24d7c5702c17e299043384' 
  AND token = 'k1Cm/KjFH9jyxSEo37pA5aa7Bp9KtCV1bAt6XCh1fvc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}