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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd48b53627bd62e1e85f5f7a7e2bdaed2a612311d3211b81e31fe6ad552f72721' 
  AND token = 'D3KHhPC6xEXis3DCm/57L1c/OTZTuVpbQZOIZt5YiLo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}