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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f7d16fc2cbd180310d41d9647f3503b1fd07b65a533a369651ec20def1ce4ec8' 
  AND token = 'Zx2DbK1tFMV+PW8tsaRGp2IY2xgFVWBExBrjcHJdjZ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}