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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '11653c693ea9453d467875853b0e4949e42c2b455561cc3e6dbb510ea21ad420' 
  AND token = 'TiAWuA3Viav45/rN9Fit0Wh4igq7x7hNVspDzSOo9nM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}