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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1cf80319b676eca812c85f10d940c4d37681d9b996f2eef38bb268e6555011ce' 
  AND token = 'xDNnLAzy60d3L+vuVuJLNHfYMr4hKM3z9fKzV3uEJoU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}