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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '435485984da0fdd4002047a88cc1b01e90c311a950b0f65f91dade5e37e3dab8' 
  AND token = 'lJfN8wE+cl0fF/eb6zW0qWO1wBTY2Jn5i9DinhOfDmQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}