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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ea23454af9522e294141dc431f3b34b7401c2a42b68878c5010d6dfbf5eda8' 
  AND token = 'lXkjRwFF2LT6j3et0J1nKWavMv6TZNggH4m1l7WC7BM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}