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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45ea38a82375409bbb1e979e40cc0d39d298ab86468d37d963a6e7c31e5f6082' 
  AND token = 'fAVDUv2Y4rQJK0Ic/iR7WFv0HcamYS7WFk/Hb9olvoo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}