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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cff3a245f8a77245daee55dd75c830f856e99b0b3b9b58dbfd8281658aa3b381' 
  AND token = 'bH4hKB4jDe2ze/cSdPyrp5y2oRzSXyMp0z8wvjuxSg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}