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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9db78c2e19b2913db8feae84baffc54688e2688546bd1086ae2b5662f03226a9' 
  AND token = 'T++byqB4zsW2EG4gsmNS9s9pmsxtf/REXIWSmIR28IU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}