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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '757f371b671492efbff2591bf12d99aeb47aa2db104d128dfb5e6238316d3ce5' 
  AND token = 'x12xODmLI1xnrFivaR/lq5IER9qPoPg93lkiGVO7Q8M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}