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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'effb535ffc4b18931dba47f8eb734a44c2258b087255235497ff2bf346a649f4' 
  AND token = 'b65AXy1KnqHY5mdokugOFF+EvogT0zoXV3pLShNCS2Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}