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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '307d21c439ff7a4ed5a3a357f3bb5b3de285da2bc8f6a51c9c0cd8217706d212' 
  AND token = 'acxwQPEVGzlrJpCB0i2zwSQAy8PRe0mUs1AWayjfqI0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}