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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '860c119981d971f72790193631b1886e8e6dd4b2c891a1e7144b733eeb6a2534' 
  AND token = 'E5x+bhIQ3Qao5j5yy3/inbpiu4LSIFxLIjYxjFdWkQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}