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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '384e0f1a5650bc9c1654fa0b79ee147d815d2e6999bb4f4d435017db454e5986' 
  AND token = 'MZ3ZuK6MhOL1WyDPlXSUUurK6wcBEBGRR4j1LCEMrUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}