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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e4480deaf4818f72c5e933f2e8e698d4efd34b91162e16507cfde6c56ffc79' 
  AND token = 'O8WkgMyxZcG13/25FpKdxT9QcjrRsZ59s7zaC8BT8RE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}